Kolahdouzan M, Hamadeh MJ. CNS Neurosci Ther. 23(4) 272-290, 2017.
Significance of the research: "Caffeine is the most widely used psychostimulant in Western countries. In Alzheimer鈥檚 disease, caffeine is beneficial in both men and women, in humans and animals. Similar effects of caffeine were observed in men with Parkinson鈥檚 disease; however, the effect of caffeine in female PD patients is controversial due to high levels of estrogen in women. Caffeine is protective in Alzheimer鈥檚 disease and Parkinson鈥檚 disease at dosages equivalent to 3-5 mg/kg. However, further research is needed to investigate the effect of caffeine on Parkinson鈥檚 disease in women. As well, the effects of caffeine in amyotrophic lateral sclerosis, Huntington鈥檚 disease and Machado-Joseph disease need to be further investigated."