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Paper of the month (September 2021) from Dr. Olivier Birot and Dr. Pierre Lemieux

Lemieux Pierre, Birot Olivier. (2021). Altitude, Exercise, and Skeletal Muscle Angio-Adaptive Responses to Hypoxia: A Complex Story. Frontiers in Physiology, V12, p146. https://www.frontiersin.org/article/10.3389/fphys.2021.735557 Significance of the research: Hypoxia, defined as a reduced oxygen availability, can be observed in many tissues in response to various physiological and pathological conditions. As a hallmark of the altitude environment, […]

Paper of the month (June 2021) from Dr. John McDermott's research group

Miyake, T., Aziz, A., & McDermott, J. C. (2020). Maintenance of the Undifferentiated State in Myogenic Progenitor Cells by TGFβ Signaling is Smad Independent and Requires MEK Activation. International journal of molecular sciences, 21(3), 1057. https://doi.org/10.3390/ijms21031057 Significance of the research: Transforming growth factor β (TGFβ) is a pluripotent cytokine that has potent effects on skeletal […]

Worried about vaccine side effects? Check out Dr. Ali Abdul-Sater's comments on Y-file

Paper of the month (May 2021) from Dr. Olasunkanme (Ola) Adegoke's research group

Mann, G., & Adegoke, O. (2021). Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells. Physiological reports, 9(1), e14673. https://doi.org/10.14814/phy2.14673 Significance of the research: Type 2 diabetes and cardiovascular diseases affect millions of people world-wide, with the attending implications for morbidity and mortality. An underlying cause of these diseases is insulin resistance, especially skeletal […]

Y-File News: Muscle Health Awareness Day features eight speakers for 12th annual event

Join Will Gage, associate vice-president, teaching & learning, and Joy Kirchner, dean of libraries, on May 6 from 1 to 4 p.m. for a non-traditional conference, Open Space for Open Education, to help shape the University’s further engagement with open educational practices and OER.

Paper of the month (April 2021) from Dr. Ronald Ceddia's research group

Da Eira, D., Jani, S., Sung, H., Sweeney, G., & Ceddia, R. B. (2020). Effects of the adiponectin mimetic compound ALY688 on glucose and fat metabolism in visceral and subcutaneous rat adipocytes. Adipocyte, 9(1), 550–562. https://doi.org/10.1080/21623945.2020.1817230   Significance of the research: Adiponectin is an adipose-derived hormone that is significantly reduced in the blood of obese and type 2 diabetic […]

Drs. Christopher Perry and David Hood interviewed in Nature Outlook for a feature on "Unlocking the mysteries of mitochondria: The Key to Endurance".

Sports Science Outlook [PDF]

Paper of the month (March 2021) from Dr. Heather Edgell's research group

Nardone M, Guzman J, Harvey PJ, Floras JS, Edgell H. Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS). J Appl Physiol (1985). 2020;128(4):907‐913. doi:10.1152/japplphysiol.00040.2020 Significance of the research: Postural orthostatic tachycardia syndrome (POTS) is marked by an excessive increase of heart rate in the upright posture […]

Paper of the month (February 2021) from Dr. Peter Backx's research group

Zhao Y, Rafatian N, Backx PH, et al. Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform. Matrix Biol. 2020;85-86:189-204. doi:10.1016/j.matbio.2019.04.001   Significance of the research The generation of heart tissues from pluripotent stem cells is hampered by the lack of cellular maturation as well as problems with cellular composition. In addition to cardiomyocytes, […]