These new findings suggest that structural changes in this collection of brain regions may be critical to Alzheimer’s disease onset and this could eventually lead to patients being diagnosed earlier.

“The default network was a vulnerable area and it was more vulnerable in those who would go on to develop the disease,” says 91��ɫ psychology Professor Gary Turner of the Cognitive Aging Neuroscience and Neurointervention Lab in the Faculty of Health.

The network of brain regions highlighted in red and yellow show atrophy in both healthy aging and neurodegenerative disease. These regions are susceptible to normal aging and dementia

Turner and Cornell University Professor , the Rebecca Q. and James C. Morgan Sesquicentennial Faculty Fellow and director of the Laboratory of Brain and Cognition at Cornell, found that the brain’s grey matter in the default network shrinks with normal aging across the lifespan, but it does so much more sharply in those who go on to develop dementia, as well as those with a genetic predisposition for the disease. These changes were also associated with declines in general cognitive ability.

“Our data suggest that these structural brain changes may be detectable many years before behavioral signs appear,” says Turner. This could allow for much earlier interventions for Alzheimer’s disease than is currently possible. Their paper, “”, was published this month online and in-print in The Journal of Neuroscience.

Turner and Spreng, co-principal investigators, measured brain volume using the brain images of 848 people, from age 18 to 94, to determine the role of the default network in neurodegenerative disease such as Alzheimer’s. They were able to analyze data collected as part of the Open Access Series of Imaging Studies, which provided a cross-sectional data set, and the longitudinal Alzheimer's Disease Neuroimaging Initiative, which looked at the same people multiple times over several years. By combining these two large datasets, the authors were able to measure brain changes from young to older adulthood and from healthy aging to neurodegenerative disease.

Gary Turner

“What we were really interested in doing with this work was looking at how the brain is altered across the lifespan,” says Turner. “The default network is already known to be implicated in Alzheimer’s disease[…]but we believe this is one of the first reports demonstrating these structural network changes across the lifespan from young to older adulthood and into Alzheimer’s disease. And we were able to look at changes simultaneously across the whole default network.”

Core areas of the network include the posterior cingulate cortex, the medial prefrontal cortex, the medial temporal lobes and the lateral parietal cortex.

They also found that these declines in brain volume were greater in the cohort who carried the APOE4 gene, a genetic marker for potentially developing Alzheimer’s disease, and those with cerebrospinal fluid biomarkers of Alzheimer’s. This shows that structural changes in the default network may be associated with genetic risk of the disease.

“These results help us to better understand the pattern of brain change that occurs across the lifespan and into neurodegenerative disease,” says Turner, who received a two-year Canadian Institutes of Health Research grant of $85,000 to complete the project. “While not a central focus of this study, we hope that with further exploration these findings may, over time,��help to inform diagnostic and prognostic decision-making in the clinic.”

In the future, Turner said this research could lay the groundwork for a new series of studies leading to better biomarkers for the disease. “Certainly, these findings highlight the importance of this network as a constellation of brain regions that warrants further study in terms of early identification of the disease.”

The focus of Turner’s research, he says, is to translate these cognitive neuroscience research findings into rehabilitation interventions to enhance cognitive functioning in healthy aging and acquired brain injury and slow the trajectory of cognitive decline in brain disease.

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Blow by Blow: The Second Annual Donald Sanderson Memorial Symposium on Sport Concussion is open to the public – athletes, coaches, parents,��researchers and anyone interested in the physical and psychological impact head injuries can have on individuals and their families.

91��ɫ’s School of Kinesiology & Health Science will host the two-hour evening event, which will bring sports medicine and brain researchers together with athletes to discuss an injury that continues to impair the careers and health of both amateur and professional athletes − most recently, hockey champion Sidney Crosby.

The symposium is held in honour of Donald Sanderson, the 91��ɫ kinesiology student and promising hockey player who died Jan. 2, 2009 as a result of a head injury during a Whitby Dunlops game. 

     Right: Matt Dunigan

"Educating our student athletes about head injuries is critical,” says Cindy Hughes, manager of the Gorman/Shore Sport Injury Clinic in 91��ɫ’s School of Kinesiology & Health Science, who helped organize the symposium. “They need to understand the importance of reporting a possible concussion right away so they can receive the proper care."

, a game analyst with TSN since 1996, played football for 14 years on five Canadian teams and was inducted into the Canadian Football Hall of Fame in 2006. He retired from football in 1996 after suffering at least a dozen diagnosed concussions, and continues to struggle with the long-term effects of those concussions. He will speak about the post-concussive symptoms he has experienced since retirement and the effect of concussion on himself and his family, as well as the importance of reporting concussion and taking it seriously. A champion of research on sport concussion, Dunigan announced last spring that upon his death his brain will be donated to Toronto’s Krembil Neuroscience Centre.

Dahna Sanderson, who established the Donald Sanderson Memorial Trust Fund in memory of her son, will also speak during the symposium. A sports mom and fan for 20 years, she coached professional figure skating and is passionate about sports and sports safety. 

is a primary care sport medicine specialist, certified in family and sports medicine in Canada and the US. Currently practising in Burlington, he has been a junior hockey team physician for the past decade in Canada and the US. He is a research chair of the Hockey Neurotrauma and Concussion Initiative Research Committee and is primary investigator of the Hockey Concussion Education Project. 

Lauren Sergio is a professor in the School of Kinesiology & Health Science in 91��ɫ’s Faculty of Health. A neuroscientist, she studies the effects of age, sex, neurological disease, head injury and experience (élite versus non-élite athletes) on the brain’s control of complex movement. She works with a wide range of adults, from NHL draft prospects to Alzheimer’s disease patients, using behavioural and brain imaging techniques. 

Left: Lauren Sergio

Roy McMurtry, 91��ɫ chancellor and former chair and chief executive officer of the Canadian Football League, will deliver opening remarks. Award-winning CBC sports reporter Teddy Katz will MC the event. 

The symposium takes place in the Price Family Cinema, Accolade East Building, from 7 to 9pm. Admission is free, but registration is required. To register and for more information on speakers, visit the symposium website.

Republished courtesy of YFile– 91��ɫ’s daily e-bulletin.

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91��ɫ West MPP Mario Sergio made the announcement Tuesday. 91��ɫ’s research investment of $50,000 will match the funds for the award. 

The Early Researcher Awards program helps promising, recently appointed Ontario researchers build research teams of undergraduates, graduate students, postdoctoral fellows, research associates and technicians. The goal of the program is to improve Ontario’s ability to attract and retain the best and brightest research talent. Ontario’s Early Researcher Awards investment will support 71 projects and 334 researchers and their teams across the province. 

Left: Derek Wilson

Wilson is researching why and how misfolded protein “amyloid plaques” form in the brain and disrupt normal brain activity – a process that can lead to the development of neurodegenerative diseases, such as Alzheimer’s disease. Wilson’s team will conduct molecular level studies, which reveal the chemical interactions and structural features of proteins that cause them to misfold and clump together. Ultimately, his research aims to understand the underlying causes of neurodegenerative diseases and help identify new approaches for treatment.  

“This funding is crucial for young researchers,” said Wilson, a chemistry professor in 91��ɫ's Faculty of Liberal Arts & Professional Studies who is also a member of 91��ɫ’s Centre for Research in Mass Spectrometry and 91��ɫ’s Centre for Research on Biomolecular Interactions. “I am grateful to the provincial government for supporting our research.”  

“The Early Researcher Awards program is a prime example of the province’s ongoing commitment to strengthen and support globally competitive research being conducted at the University,” said Robert Haché, vice-president, research & innovation, at 91��ɫ. “The awards recognize cutting-edge research that is undertaken by researchers early in their careers, as they seek effective solutions to real-world challenges.”

“We’re proud of the remarkable talent we have at 91��ɫ and the exceptional work our Toronto researchers do,” said Sergio. “Their contributions are making the world a better place, starting right here with new ideas and jobs in our community.”  

“Some of the world’s best researchers work here and across Ontario. Their ideas fuel job creation and economic growth, and our government is proud to support them,” said Glen Murray, Ontario minister of research & innovation.

Republished courtesy of YFile – 91��ɫ’s daily e-bulletin.

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Her good news: Among other benefits, the regular use of two languages appears to delay the onset of Alzheimer’s disease symptoms. Dr. Bialystok, 62, a distinguished research professor of psychology at 91��ɫ [Faculty of Health] in Toronto, was for her contributions to social science. We spoke for two hours in a Washington hotel room in February and again, more recently, by telephone. An edited version of the two conversations follows.

Q. How did you begin studying bilingualism?

A. You know, I didn’t start trying to find out whether bilingualism was bad or good. I did my doctorate in psychology: on how children acquire language. When I finished graduate school, in 1976, there was a job shortage in Canada for PhDs. The only position I found was with a research project studying second language acquisition in school children. It wasn’t my area. But it was close enough.

As a psychologist, I brought neuroscience questions to the study, like “How does the acquisition of a second language change thought?” It was these types of questions that naturally led to the bilingualism research. The way research works is, it takes you down a road. You then follow that road.

Q. So what exactly did you find on this unexpected road?

A. As we did our research, you could see there was a big difference in the way monolingual and bilingual children processed language. We found that if you gave 5- and 6-year-olds language problems to solve, monolingual and bilingual children knew, pretty much, the same amount of language.

But on one question, there was a difference. We asked all the children if a certain illogical sentence was grammatically correct: “Apples grow on noses.” The monolingual children couldn’t answer. They’d say, “That’s silly” and they’d stall. But the bilingual children would say, in their own words, “It’s silly, but it’s grammatically correct.” The bilinguals, we found, manifested a cognitive system with the ability to attend to important information and ignore the less important.

Q. How does this work – do you understand it?

A. Yes. There’s a system in your brain, the executive control system. It’s a general manager. Its job is to keep you focused on what is relevant, while ignoring distractions. It’s what makes it possible for you to hold two different things in your mind at one time and switch between them.

If you have two languages and you use them regularly, the way the brain’s networks work is that every time you speak, both languages pop up and the executive control system has to sort through everything and attend to what’s relevant in the moment. Therefore the bilinguals use that system more, and it’s that regular use that makes that system more efficient.

Q. One of your most startling recent findings is that bilingualism helps forestall the symptoms of Alzheimer’s disease. How did you come to learn this?

A. We did two kinds of studies. In the first, published in 2004, we found that normally aging bilinguals had better cognitive functioning than normally aging monolinguals. Bilingual older adults performed better than monolingual older adults on executive control tasks. That was very impressive because it didn’t have to be that way. It could have turned out that everybody just lost function equally as they got older.

That evidence made us look at people who didn’t have normal cognitive function. In our next studies, we looked at the medical records of 400 Alzheimer’s patients. On average, the bilinguals showed Alzheimer’s symptoms five or six years later than those who spoke only one language. This didn’t mean that the bilinguals didn’t have Alzheimer’s. It meant that as the disease took root in their brains, they were able to continue functioning at a higher level. They could cope with the disease for longer.

Q. So high school French is useful for something other than ordering a special meal in a restaurant?

A. Sorry, no. You have to use both languages all the time. You won’t get the bilingual benefit from occasional use.

Q. One would think bilingualism might help with multitasking – does it?

A. Yes, multitasking is one of the things the executive control system handles. We wondered, “Are bilinguals better at multitasking?” So we put monolinguals and bilinguals into a driving simulator. Through headphones, we gave them extra tasks to do – as if they were driving and talking on cellphones. We then measured how much worse their driving got. Now, everybody’s driving got worse. But the bilinguals, their driving didn’t drop as much. Because adding on another task while trying to concentrate on a driving problem, that’s what bilingualism gives you – though I wouldn’t advise doing this.

Q. Has the development of new neuroimaging technologies changed your work?

A. Tremendously. It used to be that we could only see what parts of the brain lit up when our subjects performed different tasks. Now, with the new technologies, we can see how all the brain structures work in accord with each other.

In terms of monolinguals and bilinguals, the big thing that we have found is that the connections are different. So we have monolinguals solving a problem, and they use X systems, but when bilinguals solve the same problem, they use others. One of the things we’ve seen is that on certain kinds of even nonverbal tests, bilingual people are faster. Why? Well, when we look in their brains through neuroimaging, it appears like they’re using a different kind of a network that might include language centres to solve a completely nonverbal problem. Their whole brain appears to rewire because of bilingualism.

Q. Bilingualism used to be considered a negative thing – at least in the United States. Is it still?

A. Until about the 1960s, the conventional wisdom was that bilingualism was a disadvantage. Some of this was xenophobia. Thanks to science, we now know that the opposite is true.

Q. Many immigrants choose not to teach their children their native language. Is this a good thing?

A. I’m asked about this all the time. People e-mail me and say, “I’m getting married to someone from another culture, what should we do with the children?” I always say, “You’re sitting on a potential gift.”

There are two major reasons people should pass their heritage language onto children. First, it connects children to their ancestors. The second is my research: Bilingualism is good for you. It makes brains stronger. It is brain exercise.

Q. Are you bilingual?

A. Well, I have fully bilingual grandchildren because my daughter married a Frenchman. When my daughter announced her engagement to her French boyfriend, we were a little surprised. It’s always astonishing when your child announces she’s getting married. She said, “But Mom, it’ll be fine, our children will be bilingual!”

Bialystok also holds an appointment at in Toronto. Her interview was featured on the front page of The New 91��ɫ Times and was the site's most emailed story on May 31, 2011.

Posted by Elizabeth Monier-Williams, research communications officer, with files courtesy of YFile– 91��ɫ’s daily e-bulletin.

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Pregnant with her third child, she was conducting a series of interviews as research for the play, , on loss and how it is transformed, when she lost her son Ethan. “I was just struck by how I was immersed in this phenomena and living it at the same time,” she says. I'm Still Here was co-created with 91��ɫ nursing Professor Gail Mitchell and playwright Vrenia Ivonoffski.

Right: Christine Jonas-Simpson, holding the children's book she wrote, Ethan's Butterflies

Ethan was stillborn at 38 weeks – or, as Jonas-Simpson prefers to say, born still – causing a rent in the universe as she knew it. After the loud silence of her delivery, she remembers hearing a primal scream of agony, realizing some moments later it was coming from her.

Almost a decade later, Jonas-Simpson is about to premiere her third research-based documentary film, about how mothers and their families live with the loss of a child. The premiere will take place Sunday, May 15, from 1 to 3:30pm at the Fox Theatre, 2236 Queen St. E. in Toronto. Tickets are $25 per ticket with proceeds going to Bereaved Families of Ontario-Toronto. To buy tickets, call 416-440-0290 or e-mail info@bfotoronto.ca.

Enduring Love looks at the lives of four women, the agony of loss, the impact the death of their infant has had on them and their families and how they learned to live with their loss. It also traces the importance of recognizing their other children are also grieving, the continuing presence of their deceased child in their lives, the rituals they’ve developed and how they not only endured but have been transformed by their loss. Funded by 91��ɫ's Faculty of Health and the Health Leadership & Learning Network: Interprofessional Education Initiative Fund, the documentary answers the research question, what is the meaning of living and transforming with loss for mothers who experience the loss of their baby?

As one woman in the film says of her family, it was a “seminal event in their lives”; there was a before and an after. The women make the point that many fail to realize that losing their baby, whether at 24 weeks gestation or several weeks after delivery, is a profoundly felt loss that changes, not only them, but their husbands and their children, forever. One of the universally hard moments for these women was going home from the hospital without their baby. It feels so unnatural, says Jonas-Simpson.

It was the experience of losing her own son that guided Jonas-Simpson’s research toward providing a body of arts-based research for others who experienced perinatal loss. She had often used music in her nursing practice and research, and then began incorporating art, drama and film. “With grieving and loss it seemed appropriate to keep going with the arts.” Although, she will write papers on her latest research, she believes presenting her findings with an art-based approach makes it more accessible and touches people in a way a research paper in a journal wouldn’t. “It’s a way of showing the human experience, rather than just telling,” she says.

Being a researcher, I looked at the literature to see what was out there. I was struck by how little there was out there in light of grieving and loss about mothers’ lived experiences. My graduate student, Jennifer Noseworthy, and I are conducting a comprehensive literature review and we’ve only found a few qualitative studies focused on the human lived experience of perinatal loss.” And that moved Jonas-Simpson to conduct research and create resources for others like her.

Enduring Love is her third film. Her first was , while her second, is a short made from footage shot for Enduring Love, which focuses on the surviving children. “These children have an incredible bond and relationship with the babies,” their siblings who’ve died. Jonas-Simpson recently gave a talk and showed Why Did Baby Die? at a Women's Health and Mental Wellbeing Speakers Series event at 91��ɫ.

Some of the children, as seen in Enduring Love, have drawn family portraits years later that have included their deceased siblings. “Grieving and loss isn’t always something we talk about openly, but it is experienced by many, if not all, of us,” says Jonas-Simpson. Even after the physical death, the relationship continues. “It’s still hidden. Perinatal loss is also disenfranchised in our society.” To help grieving children with the loss of a baby sibling, she also wrote the children's book .

Jonas-Simpson started talking about her own experience of losing Ethan, born with vibrant red locks, and how her other two sons, now 11 and 13, have integrated him into their lives as a way to help others. “The children integrate this loss very well,” she says. One of her children even wrote a letter to Ethan as a school assignment, asking if there are dinosaurs in heaven and if it hurt to die. The teacher may have been uncomfortable, but Jonas-Simpson says it’s important to talk about and to understand the continuing relationship following death.

Next, she is hoping to do research on children age three to 18 who are grieving a loss of a baby sibling. Children, she says, are often forgotten about, but they too grieve. “If we can be more open about grief and loss as a natural human experience and if we can begin in the schools with that,” it could be really helpful for the children, she says. She would also like to explore the common and unique threads of grieving around the world.

For more information or to view or buy Jonas-Simpson’s films, visit the Faculty of Health’s Living and Transforming with Perinatal Loss website.

By Sandra McLean, YFile writer

Republished courtesy of YFile – 91��ɫ’s daily e-bulletin.

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91��ɫ Professors Chris Ardern, , Paul Ritvo and Lauren Sergio will work on site for one to two days a week with hospital clinicians to foster research collaborations and knowledge exchange, and engage in joint knowledge mobilization efforts.

The partnership will realize important benefits to the research communities at both institutions and for the general public, says 91��ɫ Professor (right), associate vice-president research, science & technology, who led the effort to develop the partnership with Southlake Regional Health Centre.

"The embedded 91��ɫ researchers are senior scientists who will explore and cultivate research collaborations between 91��ɫ and Southlake researchers and clinicians," says Siu. "They will act as 'matchmakers' and brokers and will bring 91��ɫ's research expertise and knowledge to Southlake to facilitate collaboration.

"The partnership will broaden the research capacity for both 91��ɫ researchers and the Southlake clinicians," says Siu. "91��ɫ does not have a Faculty of Medicine or a teaching hospital. As a result,��University researchers do not have the patient access they would like to have. By working with Southlake,��the University is enhancing a collaboration that would benefit both parties."

The embedded University scientists bring to Southlake Regional Health Centre their recognized expertise in biomedical and health research. Southlake is the only community-based hospital in Ontario to offer six regional tertiary programs, including child and adolescent mental health, maternal and child,��cardiac and cancer care.

"We anticipate this to be an outstanding opportunity for both Southlake and 91��ɫ," says , director of research at Southlake.

"Serving some 1.5 million people through our regional programs and providing tertiary level care in many areas, the depth and breadth of programs and services, and the unexplored opportunities for reasearch collaboration between Southlake and 91��ɫ are endless," says Clifford.

"Southlake is interested in strengthening its research in terms of breadth and depth and in fact, Southlake is developing a research institute with a plan to become a teaching hospital with an official affiliation with a Canadian university," says Siu.

91��ɫ is a preferred candidate for this kind of partnership with Southlake, says Siu,��because the two institutions have shared goals and visions, and a willingness to work together.

The partnership offers exceptional training and educational opportunities for graduate and undergraduate students working in the research teams, says Siu.

In addition, the opportunity presented by the collaboration between the two institutions is consistent with the goal of integrating teaching and research with the world outside the University that was articulated in 91��ɫ's recent .

More about the 91��ɫ-Southlake embedded researchers

Chris Ardern (left) is a professor in the School of Kinesiology & Health Science in 91��ɫ's Faculty of Health. His current research interests include the epidemiology of physical activity, obesity and cardiometabolic risk. His most recent work has focused on the use of risk algorithms, behavioural profiling and trajectory modelling approaches to identify high-risk subgroups for the development of the metabolic syndrome and cardiovascular disease mortality. Arden is currently investigating the role of geospatial analysis to improve the surveillance of cardiovascular disease in 91��ɫ Region, and is a co-investigator on the Pre-diabetes Detection & Physical Activity Intervention and Delivery (PRE-PAID) program, a six-month trial of culturally-preferred physical activity. Ardern will be embedded in Southlake's chronic disease portfolio.

In her research, (right) works on a family of proteins known as nucleoside transporters. These transporters play significant roles in a number of clinical settings because they transport drugs used in cancer and are targets of drugs used in some cardiac care settings. Despite their clinical relevance, Coe, who is a professor of biology in 91��ɫ's Faculty of Science & Engineering, says researchers know very little about how these transporters work and how they differ in terms of their distribution, activity and regulation in individual patients. Using a molecular diagnostics approach, Coe and her team will work with Southlake clinicians from both the cardiac care and oncology portfolios to investigate the transporter profiles in individual patients and correlate these profiles with drug treatments and outcomes. The ultimate goal of this work is to contribute to the efforts to develop more personalized approaches to the treatment of disease.

Paul Ritvo (left) is a behavioural scientist who will serve as the research adviser, physical and mental health liaison and special projects scientist. A professor in 91��ɫ’s Faculty of Health, Ritvo’s research interests focus on electronic health interventions that employ cell phones, smartphones and online programs to change health behaviours in diabetics, HIV-positive individuals and individuals with mental health difficulties. Ritvo will work with Southlake clinicians to extend current intervention studies that use Blackberry smartphones and innovative software applications to help patients reduce health risks by way of healthy exercise, diet and improved medication adherence.

Lauren Sergio (right) is a neuroscientist working in 91��ɫ's Sherman Health Science Research Centre. Her current research projects examine the effects of age, sex, neurological disease and past head injuries (of athletes versus non-athletes) on the brain's control of complex movement. In her role with Southlake Regional Health Centre, Sergio will be an embedded researcher in the chronic disease, emergency medicine and surgical portfolios. She works with a wide range of adult populations, including professional hockey players and Alzheimer's disease patients. Her findings have implications for neurological disease diagnosis and rehabilitation and for understanding the fundamental brain mechanisms for movement control. She is using cognitive-motor integration research to test if new instrumentation developed in her laboratory can differentiate between types of dementia. She is also researching the long-term effects of concussion in young athletes. Sergio is a member of the .

The embedded researcher program at Southlake Regional Health Centre is an example of the collaboration between the Faculty of Science & Engineering and the Faculty of Health at 91��ɫ and is part of an ongoing commitment by the Faculties' deans to work together.

For more information on 91��ɫ's partnerships with regional hospitals, see YFile,��April 17, 2009 and  April 21, 2009.

By Jenny Pitt-Clark, YFile editor.

Republished courtesy of YFile – 91��ɫ’s daily e-bulletin.

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These benefits come from having a brain that’s constantly juggling two – or even more – languages, said Ellen Bialystok, [Distinguished Research Professor in Psychology, ] at 91��ɫ in Toronto, who spoke at the AAAS annual meeting. For instance, a person who speaks both Hindi and Tamil can’t turn Tamil off even if he’s speaking to only Hindi users, because the brain is constantly deciding which language is most appropriate for a given situation.

This constant back-and-forth between two linguistic systems means frequent exercise for the brain’s so-called executive control functions, located mainly in the prefrontal cortex. This is the part of the brain tasked with focusing one’s attention, ignoring distractions, holding multiple pieces of information in mind when trying to solve a problem, and then flipping back and forth between them.

“If you walk into a room, there are a million things that could attract your attention,” Bialystok said. “How is it we manage to focus at all? How does our mind pay attention to what we need to pay attention to without getting distracted?”

To test one’s ability to identify pertinent nuggets while being bombarded with extraneous information, scientists use something called the Stroop test. Subjects are presented with a word for a particular colour and asked to identify the colour of ink it’s printed in. So if the word is “blue” and it’s printed in blue, no problem. If, on the other hand, the word “blue” is printed in red, they have to sort out which piece of information – the colour of the ink, or the colour being spelled out – is the one they need.

“This is extremely hard to do, because it’s terribly difficult to block out the information from the word,” Bialystok said.

In monolingual speakers, this kind of mental curveball will add 240 milliseconds to their reaction time – a significant delay, in brain reaction terms. Bilingual people, on the other hand, take just 160 extra milliseconds to sort this out. Bialystok theorizes that it’s because they’re used to prioritizing information in potentially confusing situations all day.alz

Those advantages aren’t just useful for schoolchildren – they last over the course of a lifetime. A study published last year in the journal Neurology surveyed 211 patients diagnosed with Alzheimer’s and found that those who spoke only one language saw the onset of their first symptoms four to five years earlier than their bilingual peers. While knowing two languages doesn’t fight the disease, it does strengthen those parts of the brain that are susceptible to dementia’s early attacks, allowing them to withstand the assault much longer.

Republished courtesy of YFile – 91��ɫ’s daily e-bulletin.

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The more proficient you become, the better, but "every little bit helps," said Ellen Bialystok, a psychology professor at 91��ɫ [Faculty of Health].

Much of the study of bilingualism has centered on babies, as scientists wondered why simply speaking to infants in two languages allows them to learn both in the time it takes most babies to learn one. Their brains seem to become more flexible, better able to multi-task. As they grow up, their brains show better "executive control," a system key to higher functioning – as Bialystok puts it, "the most important part of your mind."

Bialystok studied 450 Alzheimer's patients, all of whom showed the same degree of impairment at the time of diagnosis. Half are bilingual – they've spoken two languages regularly for most of their lives. The rest are monolingual.

The bilingual patients had Alzheimer's symptoms and were diagnosed between four and five years later than the patients who spoke only one language, she told the annual meeting of the American Association for the Advancement of Science.

Being bilingual does nothing to prevent Alzheimer's disease from striking. But once the disease does begin its silent attack, those years of robust executive control provide a buffer so that symptoms don't become apparent as quickly, Bialystok said. "They've been able to cope with the disease," she said.

Her work supports an earlier study from other researchers that also found a protective effect.

But people don't have to master a new language to benefit some, Bialystok said. Exercising your brain throughout life contributes to what's called "cognitive reserve", the overall ability to withstand the declines of aging and disease. That's the basis of the use-it-or-lose-it advice from aging experts, who also recommend such things as crossword puzzles to keep your brain nimble. "If you start to learn at 40, 50, 60, you are certainly keeping your brain active," she said.

Newspapers and online news sites around the world reported on Bialystok’s lecture remarks, including media across Canada, the US, Australia, Bangladesh, China, England, Iran, Ireland, India, Malaysia, Mexico, New Zealand, Qatar, South Africa, Scotland and Wales.

Bialystok’s study was also features in stories on radio and television stations around the world, including major networks in the US and Canada.

Republished courtesy of YFile – 91��ɫ’s daily e-bulletin.

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She accepted the Institute of Aging at the annual conference of the Canadian Association on Gerontology in Montreal. The prize, which augments major scholarship funding she has already received,��included the money, an invitation to the conference and, best of all, a chance to adjudicate research posters.

“It’s perfect timing for me,” says the first-year doctoral student in the Faculty of Health's School of Kinesiology & Health Science. “I’ll be able to see what’s going on in my field. Winning this award has been very motivating."

Hawkins started work this fall developing and evaluating a clinical assessment tool to measure visuomotor integration (hand-eye coordination) that could lead to early detection of Alzheimer’s disease. For this, CIHR is funding her research to the tune of $35,000 a year – $30,000 in salary plus $5,000 research allowance – for each of the next three years. It’s the biggest scholarship Hawkins has ever received.

Left: Kara Hawkins

Sit down with Hawkins at her corner desk in the office she shares with other graduate students and you’ll notice only one image taped to the wall next to her computer. “That’s my brain,” says the 27-year-old of the vertical MRI scan taken this fall in 91��ɫ’s new Neuroimaging Laboratory, located in the Sherman Health Science Research Centre.

The brain. Hawkins became fascinated with it early in her undergraduate years. "You can't understand behaviour without understanding the brain. That's what interested me most." She started studying psychology then branched into kinesiology. It was a natural detour. “I’m an athlete,” says the former varsity goalie who now plays forward for the Aurora Panthers and for the Ice-O-Topes, an intramural team at 91��ɫ. “I wanted to learn how the brain controls movement.”

After graduating in 2006, she jumped at an offer to work as a neuropsychology assistant at Baycrest, a centre specializing in geriatric research and care. “I’ve always been interested in clinical applications,” says Hawkins. Baycrest sparked an interest in aging and two years later she returned to 91��ɫ to pursue a master’s degree and neuroscience graduate diploma, delving deeper into the neurophysiology of complex motor control. She won three scholarships to do it and graduated last spring.

Now a doctoral student, she’s back in a clinical setting. At 91��ɫ Central Hospital, she is collaborating with the geriatric physician to diagnose aging patients who show signs of mental deterioration. Currently, doctors use language, cognition, memory and attention tests to score patients’ mental status out of 30. It’s an imprecise science, and Hawkins has developed and is testing a new measurement tool that could be more precise.

The tool looks like a laptop. There are two touch-sensitive screens, one vertical and the other horizontal (where the keyboard would normally be). The patient is instructed to reach for a target that appears on the vertical screen, at first directly with her hand and then more indirectly using the horizontal touch screen to manipulate a cursor. The test is not educationally or language biased, and Hawkins can determine which part of the brain the patient is using and the level of dysfunction based by the accuracy and speed of the response.

The brain is a complex network of communicating parts. When someone has dementia, the lines of communication deteriorate and misfire. Hawkins’ test aims to detect the breakdown in the visual-motor and cognitive-motor communication lines. “These touch-screen tracking tests tap into that.”

Hawkins is currently trying to recruit 60 to 90 patients diagnosed with Alzheimer’s disease and the same number who are aging normally. Over the next three years, she’ll test her diagnostic tool. She is particularly interested in finding out if it can detect early and more subtle stages of Alzheimer’s disease. Interested participants may contact her at karah@yorku.ca.

The earlier we can catch signs of mental deterioration, the more time there will be for intervention that could delay the onset, says Hawkins. Earlier and more precise diagnosis could lead to better education and better care for patients, she says.

Hawkins, now a member of the , is doing her research under the supervision of  Prof. Lauren Sergio, an expert in hand-eye coordination and director of 91��ɫ’s Sensorimotor Neuroscience Laboratory. When she’s finished her PhD, she hopes to continue exploring diseases associated with aging.

By Martha Tancock, YFile contributing writer

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The study, published today in the journal , follows up on a 2007 study led by 91��ɫ, which found that lifelong use of two or more languages keeps symptoms of Alzheimer’s and other forms of dementia at bay (see YFile, Jan. 15, 2007).

Led by the , the current study examined the clinical records of more than 200 patients diagnosed with probable Alzheimer’s disease in the Sam & Ida Ross Memory Clinic at Toronto’s Baycrest Research Centre for Aging and the Brain.

"All the patients in the study had been diagnosed with Alzheimer’s, so clearly bilingualism does not prevent the onset of dementia," says study co-author Ellen Bialystok (right), Distinguished Research Professor of psychology in 91��ɫ’s and associate scientist at the Rotman Research Institute, which is part of Baycrest.

"Instead, our results show that people who have been lifelong bilinguals have built up a cognitive reserve that allows them to cope with the disease for a longer period of time before showing symptoms," she says.

While the brains of bilingual patients did show deterioration, researchers believe that the use of more than one language equips them with compensatory skills that keep symptoms like memory loss and confusion in check.

The research team included Fergus Craik, senior scientist at the Rotman Research Institute, and Dr. Morris Freedman, professor in the University of Toronto’s Faculty of Medicine (Neurology), and scientist at the Rotman Research Institute. They found that bilingual patients were diagnosed with Alzheimer’s 4.3 years later and had reported the onset of symptoms five years later than those who spoke only one language. The groups were equivalent on measures of cognitive and occupational level; there was no apparent effect of immigration status, and there were no differences between genders.

The Neurology paper replicates findings from the team’s 2007 study led by Bialystok and published in Neuropsychologia. That study examined the clinical records of 184 patients diagnosed with probable Alzheimer’s and other forms of dementia. It found that bilingual patients delayed the onset of their symptoms by four years compared to monolingual patients.

"Overall, bilingualism should be seen as an important tool for healthy aging, along with exercise, diet, and other lifestyle choices," Bialystok says. "It’s also another reason to encourage people in multicultural societies like ours to keep speaking their native tongue and pass it along to their children," she says.

The study was funded in part by grants from the (CIHR) and the to 91��ɫ and the Rotman Research Institute.

Republished courtesy of YFile– 91��ɫ’s daily e-bulletin

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