hypertension Archives | Research & Innovation

High doses of vitamin D might affect Lou Gehrig's disease

fmaquito — Wed, 04 Jan 2012 10:00:00 +0000

High daily doses of vitamin D may improve the quality of life for patients diagnosed with Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig’s disease, a study at 91��ɫ has found.

Using an animal model, the study’s researchers found that the motor performance and muscle endurance of mice with ALS improved when they were given higher than normal doses of vitamin D.

“We are the only group in Canada that is looking at the connection between dietary interventions and the effects on the ALS model,” says 91��ɫ kinesiology Professor Mazen Hamadeh (left) of the University’s Muscle Health Research Centre in the Faculty of Health. Hamadeh supervised the research led by 91��ɫ master of science degree students Jesse Solomon and Alexandro Gianforcaro in the School of Kinesiology & Health Science.

The researchers conducted three different studies looking at different amounts of vitamin D. The first looked at the effects of 10 times the adequate intake of vitamin D on the ALS animal model – the equivalent of 8,000 IU/day in humans. Results showed an improvement in both motor performance and endurance, but no change to disease outcomes, such as onset, progression or lifespan.

“We followed up with another study because we thought we didn’t give high enough amounts of vitamin D,” says Hamadeh. In the second study, the amount of vitamin D was increased to 50 times the suggested adequate intake amount or the equivalent of 40,000 IU per day in humans. Again, there was definite improvement in functional outcomes, but not in disease outcomes, confirming the findings of the first study, he says.

The researchers then thought that perhaps the recommended adequate intake amount of vitamin D was set too high and there was already an overabundance of vitamin D being administered. That led to a third study where only one fortieth of the recommended adequate intake amount was administered using the animal model, which induced a vitamin D deficiency. This study was published in PLoS ONE, an international online peer-reviewed journal, on Dec. 27.

This third study produced some interesting results, says Hamadeh. When vitamin D deficiency was induced before disease onset, disease severity was reduced, but after disease onset, it was worse. “So at very low levels there is something happening in the cell that is causing them to function better only for a little bit of time, only until disease onset, than they progress regularly,” he says.

The key now is to find out what molecular changes are occurring in the muscle, spinal cord and brain when vitamin D is administered, and that is what Hamadeh and his students are currently working on.

“ALS is the most common motor neuron disease and up until now there is no cure for it. It is also a fast-progressing disease. Between diagnosis and death, there are usually two to five years. We are trying to see whether by modulating the diet, by changing the diet, we can influence not only when the disease starts, but how fast it progresses and whether it can affect lifespan,” says Hamadeh.

“To find a dietary intervention that could influence a fast-paced disease after diagnosis of the disease, meaning after some irreversible damage has happened, means this particular nutrient has to be very powerful to either halt or slow the pace of the disease.”

The model Hamadeh works with suffers from heightened oxidative stress, a state of increased levels of free radicals or oxidants that are produced naturally inside the cell during normal functioning and metabolism. There is an association between oxidative stress and chronic, metabolic, autoimmune, neurodegenerative and neuromuscular diseases, including ALS, Type 1 and Type 2 diabetes, cardiovascular disease, obesity, hypertension, Alzheimer’s, Parkinson’s and multiple sclerosis.

Hamadeh hopes his research and that of his students will help not only ALS, but many other similar diseases that share common mechanisms with ALS.

By Sandra McLean, YFile writer

Republished courtesy of YFile– 91��ɫ’s daily e-bulletin.

The post High doses of vitamin D might affect Lou Gehrig's disease appeared first on Research & Innovation.

Professor Sherry Grace's study shows positive benefits of cardiac rehab participation

fmaquito — Tue, 15 Feb 2011 10:00:00 +0000

Health care practitioners can increase the number of patients referred to a cardiac rehabilitation program by more than 40 per cent, helping them to reduce their risk of dying and improve their quality of life, say researchers at the Peter Munk Cardiac Centre.

Researchers explored multiple strategies to increase referrals to cardiac rehabilitation programs at 11 hospitals across Ontario, including using a discharge checklist for doctors, electronic referral in medical records and talking with patients at the bedside.

According to the study, “Effect of Cardiac Rehabilitation Referral Strategies on Utilization Rates”, published in the Feb. 14 edition of the journal , a combined approach – a checklist or electronic referral and talking with patients – can increase referrals by 45 per cent. By targeting both health care providers and patients, more than 70 per cent of patients enrol in cardiac rehab.

“Every patient discharged from the hospital with a heart condition should be referred to a cardiac rehab program,” says 91��ɫ kinesiology & health science Professor Sherry Grace, principal investigator and director of research for the Cardiovascular Rehabilitation & Prevention Program at the Peter Munk Cardiac Centre, which is part of the University Health Network in Toronto.

“Cardiac rehab is a key component of the continuum of cardiac care. We shouldn’t just discharge patients from the hospital without ensuring there is a link to these proven rehab services to support patients in their recovery,” says Grace.

Cardiac rehabilitation offers a comprehensive approach to health by combining medical treatments and lifestyle modification. Patients are able to benefit from a variety of services, including: education sessions, nutritional assessment with a dietitian, risk factor treatment (hypertension, cholesterol and smoking cessation) by physicians and nurse practitioners, medication review with a pharmacist, targeted exercise prescription by an exercise physiologist, nurse or kinesiologist and supervised exercise.

indicate that participating in cardiac rehab after a cardiac illness, such as a heart attack, can reduce the risk of death by approximately 25 per cent, a reduction similar to that of other standard therapies such as cholesterol-lowering medications (statins) and aspirin. In spite of this evidence, only 20 to 30 per cent of patients are referred to a cardiac rehabilitation program after hospital discharge, a phenomenon observed in many countries.

Joe Walters, 55, lost 30 pounds through the centre’s Cardiac Rehabilitation Program at Toronto Western Hospital (TWH) after having being diagnosed with an irregular heartbeat in August 2009.

“The cardiac rehab program was truly motivational. It opened my eyes to the number of people who have heart problems like me, and it was refreshing to know it came with a built-in support network,” says Walters, who notes work-related stress contributed to his weight gain and heart trouble. “I highly recommend a cardiac rehab program for anyone with a heart condition.”

Walters graduated from the program in April 2010, but continues to attend classes to keep the weight off.

Dr. Caroline Chessex, medical doctor and clinical director of the Cardiovascular Rehabilitation & Prevention Program at the centre, is part of a multidisciplinary team who treats patients like Walters by developing a personalized exercise program tailored to each patient's cardiac risk profile.

“Our goal is to develop strategies for patients to reduce or eliminate their risk of coronary artery disease, prevent or minimize hospitalization, decrease mortality and improve quality of life,” says Chessex, noting that patients can prolong their life and reduce their risk of having a second heart attack, or needing a second heart surgery.

Beyond the physical and psychological benefits, cardiac rehabilitation saves money. Cardiac bypass surgery, the most common type of open-heart surgery, costs approximately $23,000 for each patient, but rehabilitation costs $1,000 to 1,500 per patient.

“The return on investment is obvious. Focusing on expensive cardiac interventions and then discharging patients without a systematic approach for support just doesn’t make sense,” says Grace. “Cardiac rehab is the right step towards prevention and it saves money.”

The (CIHR) and the funded this study.

Republished courtesy of YFile– 91��ɫ’s daily e-bulletin

The post Professor Sherry Grace's study shows positive benefits of cardiac rehab participation appeared first on Research & Innovation.