Paul Ritvo Archives | Research & Innovation

Better care aim of hospital research partnership between 91��ɫ and Southlake

fmaquito — Fri, 18 Mar 2011 08:00:00 +0000

If you're a patient at Southlake Regional Health Centre, there's now a better chance you'll be part of a research project, wrote the Newmarket Era March 16; the story also appeared on :

A will embed leading scientists from the postsecondary institution as researchers to work alongside hospital clinical staff and physicians, director of research Patrick Clifford said.

Three researchers and one special projects expert will work with staff to help turn ideas into action that could result in improved patient care and results.

The hospital has 225 research projects on the go, but Mr. Clifford hopes having these experts on hand will increase that number significantly as he feels more research needs to be done in the area of clinical care.

With 500 physicians and 3,000 staff, more than half of whom are specialists in a certain field, there are plenty of ideas at Southlake. Access to experienced researchers will allow those ideas to be developed into active research projects that evaluate how change could affect a patient, he added. “It gives the staff who have ideas a person to turn to learn how to translate the idea from their head into a research study,” Mr. Clifford said.

Each of the three research scientists will be at the hospital one to two days per week and have been assigned to specific programs, including cancer and cardiac, mental health and the surgery and chronic disease programs.

Formal meetings and an open-door policy will allow staff and the researchers to interact on a regular basis to collaborate, exchange knowledge and engage each other. The initiative will strengthen Southlake’s transition into a teaching hospital as the knowledge achieved can be passed down to students.

91��ɫ University doesn’t have a faculty of medicine or a teaching hospital and this opportunity will give the researchers greater access to patients. “The partnership will be beneficial to both parties involved as well as the patients we serve,” Mr. Clifford said.

91��ɫ professors Chris Ardern, , Paul Ritvo and Lauren Sergio will be working on-site when the initiative launches next month.

Mr. Ardern is a professor in the school of kinesiology and health science and is focused on research involving epidemiology of physical activity, obesity and cardio metabolic risk. He is investigating the role of geospatial analysis to improve the surveillance of cardiovascular disease in 91��ɫ Region and is co-investigator on pre-diabetes detection and physical activity intervention and delivery program. He will work with the hospital’s chronic disease department.

Ms Coe, a biology professor, is working to develop more personalized approaches to disease treatment. She works with proteins that transport drugs used in cancer and cardiac care. Her research in Southlake’s cardiac care and oncology programs will examine how these proteins work in each individuals.

Neuroscientist Ms Sergio examines the effects of age, gender, neurological disease and past head injuries on the brain’s control of complex movement. She will work with clinicians from Southlake’s chronic disease, emergency medicine and surgical programs.

Mr. Ritvo specializes in behaviour and will serve as the research adviser, physical and mental health liaison and special projects scientist. His current research includes electronic health interventions, using cellphones, smartphones and online programs to alter the habits of diabetics and individuals with HIV and mental health issues. He will work with Southlake clinicians to examine how innovative software applications and technology can help patients reduce health risks through healthy exercise, diet and improved medication administration.

Lauren Sergio is also a member of the .

Posted by Elizabeth Monier-Williams, research communications officer, with files courtesy of YFile – 91��ɫ’s daily e-bulletin.

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New partnership embeds 91��ɫ researchers at Southlake Hospital

fmaquito — Mon, 14 Mar 2011 08:00:00 +0000

A new research initiative involving a partnership between 91��ɫ and in Newmarket will see feature leading scientists from the University serving as embedded researchers at the hospital.

91��ɫ Professors Chris Ardern, , Paul Ritvo and Lauren Sergio will work on site for one to two days a week with hospital clinicians to foster research collaborations and knowledge exchange, and engage in joint knowledge mobilization efforts.

The partnership will realize important benefits to the research communities at both institutions and for the general public, says 91��ɫ Professor (right), associate vice-president research, science & technology, who led the effort to develop the partnership with Southlake Regional Health Centre.

"The embedded 91��ɫ researchers are senior scientists who will explore and cultivate research collaborations between 91��ɫ and Southlake researchers and clinicians," says Siu. "They will act as 'matchmakers' and brokers and will bring 91��ɫ's research expertise and knowledge to Southlake to facilitate collaboration.

"The partnership will broaden the research capacity for both 91��ɫ researchers and the Southlake clinicians," says Siu. "91��ɫ does not have a Faculty of Medicine or a teaching hospital. As a result,��University researchers do not have the patient access they would like to have. By working with Southlake,��the University is enhancing a collaboration that would benefit both parties."

The embedded University scientists bring to Southlake Regional Health Centre their recognized expertise in biomedical and health research. Southlake is the only community-based hospital in Ontario to offer six regional tertiary programs, including child and adolescent mental health, maternal and child,��cardiac and cancer care.

"We anticipate this to be an outstanding opportunity for both Southlake and 91��ɫ," says , director of research at Southlake.

"Serving some 1.5 million people through our regional programs and providing tertiary level care in many areas, the depth and breadth of programs and services, and the unexplored opportunities for reasearch collaboration between Southlake and 91��ɫ are endless," says Clifford.

"Southlake is interested in strengthening its research in terms of breadth and depth and in fact, Southlake is developing a research institute with a plan to become a teaching hospital with an official affiliation with a Canadian university," says Siu.

91��ɫ is a preferred candidate for this kind of partnership with Southlake, says Siu,��because the two institutions have shared goals and visions, and a willingness to work together.

The partnership offers exceptional training and educational opportunities for graduate and undergraduate students working in the research teams, says Siu.

In addition, the opportunity presented by the collaboration between the two institutions is consistent with the goal of integrating teaching and research with the world outside the University that was articulated in 91��ɫ's recent .

More about the 91��ɫ-Southlake embedded researchers

Chris Ardern (left) is a professor in the School of Kinesiology & Health Science in 91��ɫ's Faculty of Health. His current research interests include the epidemiology of physical activity, obesity and cardiometabolic risk. His most recent work has focused on the use of risk algorithms, behavioural profiling and trajectory modelling approaches to identify high-risk subgroups for the development of the metabolic syndrome and cardiovascular disease mortality. Arden is currently investigating the role of geospatial analysis to improve the surveillance of cardiovascular disease in 91��ɫ Region, and is a co-investigator on the Pre-diabetes Detection & Physical Activity Intervention and Delivery (PRE-PAID) program, a six-month trial of culturally-preferred physical activity. Ardern will be embedded in Southlake's chronic disease portfolio.

In her research, (right) works on a family of proteins known as nucleoside transporters. These transporters play significant roles in a number of clinical settings because they transport drugs used in cancer and are targets of drugs used in some cardiac care settings. Despite their clinical relevance, Coe, who is a professor of biology in 91��ɫ's Faculty of Science & Engineering, says researchers know very little about how these transporters work and how they differ in terms of their distribution, activity and regulation in individual patients. Using a molecular diagnostics approach, Coe and her team will work with Southlake clinicians from both the cardiac care and oncology portfolios to investigate the transporter profiles in individual patients and correlate these profiles with drug treatments and outcomes. The ultimate goal of this work is to contribute to the efforts to develop more personalized approaches to the treatment of disease.

Paul Ritvo (left) is a behavioural scientist who will serve as the research adviser, physical and mental health liaison and special projects scientist. A professor in 91��ɫ’s Faculty of Health, Ritvo’s research interests focus on electronic health interventions that employ cell phones, smartphones and online programs to change health behaviours in diabetics, HIV-positive individuals and individuals with mental health difficulties. Ritvo will work with Southlake clinicians to extend current intervention studies that use Blackberry smartphones and innovative software applications to help patients reduce health risks by way of healthy exercise, diet and improved medication adherence.

Lauren Sergio (right) is a neuroscientist working in 91��ɫ's Sherman Health Science Research Centre. Her current research projects examine the effects of age, sex, neurological disease and past head injuries (of athletes versus non-athletes) on the brain's control of complex movement. In her role with Southlake Regional Health Centre, Sergio will be an embedded researcher in the chronic disease, emergency medicine and surgical portfolios. She works with a wide range of adult populations, including professional hockey players and Alzheimer's disease patients. Her findings have implications for neurological disease diagnosis and rehabilitation and for understanding the fundamental brain mechanisms for movement control. She is using cognitive-motor integration research to test if new instrumentation developed in her laboratory can differentiate between types of dementia. She is also researching the long-term effects of concussion in young athletes. Sergio is a member of the .

The embedded researcher program at Southlake Regional Health Centre is an example of the collaboration between the Faculty of Science & Engineering and the Faculty of Health at 91��ɫ and is part of an ongoing commitment by the Faculties' deans to work together.

For more information on 91��ɫ's partnerships with regional hospitals, see YFile,��April 17, 2009 and April 21, 2009.

By Jenny Pitt-Clark, YFile editor.

Republished courtesy of YFile – 91��ɫ’s daily e-bulletin.

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New diabetes study on Type 2 diabetes, high-risk populations and fitness enters second phase

fmaquito — Tue, 04 May 2010 08:00:00 +0000

Could screening high-risk populations for pre-diabetes and setting them up with culturally preferred fitness regimes prevent people from developing Type 2 diabetes and the secondary complications of heart and kidney disease, blindness and stroke?

That’s what several 91��ɫ researchers are hoping to find out. If successful, their Pre-Diabetes Detection and Physical Activity Intervention Delivery (PRE-PAID) Program could become the model for provincewide intervention.

91��ɫ Professors Michael Riddell, Norman Gledhill, Veronica Jamnik, Chris Ardern, Jennifer Kuk and Paul Ritvo in the School of Kinesiology & Health Science’s Physical Activity & Chronic Disease Unit in the Faculty of Health, along with 91��ɫ PhD candidate Chip Rowan, PRE-PAID project coordinator, are now deep into Phase 2 of their study and so far the results are promising. They have found there is an overwhelming need for programs such as PRE-PAID, as a high percentage of the participants tested already had pre-diabetes. In addition, there is a real lack of close and affordable fitness programs.

Right: From left, Michael Riddell, Veronica Jamnik, Chip Rowan and 91��ɫ students and certified exercise physiologists Ajay Rampersad and Thomas Bok

The researchers also found that to reach people in high-risk areas they need to tap into existing social networks and make community contacts, as traditional media campaigns are not that helpful. With community engagement, they were able to increase their visibility and build partnerships to fight diabetes.

The goal of the PRE-PAID program is to identify those individuals from the highest risk populations, including Chinese, South Asian, African and African-Caribbean, who have pre-diabetes, and to provide them with targeted, accessible and monitored fitness programs, and hopefully prevent them from developing Type 2 diabetes.

It could save lives and millions of health-care dollars. Health-care costs for the treatment of persons with diabetes in Canada amounts to $9 billion annually. In recognition of this burden, the Ontario Ministry of Health & Long-Term Care has made the treatment and management of diabetes a priority.

“The costs are anywhere between $2,000 and $15,000 a year per person with diabetes in direct and indirect costs, but if we can get that down to around $200 a year in investment for those with pre-diabetes to prevent the disease, that would save a lot. Not only that, but we can probably prevent six cases out of 10,” says Riddell. “We have to show this model will work and will save money in the long run over the health-care costs caused by the complications of diabetes. If we invest now in treating pre-diabetes, it will cost less in the future.”

Left: A participant undergoes a finger prick blood test to check sugar levels

The PRE-PAID Program has screened some 428 people, aged 35 to 64, from the communities of 91��ɫ, Jane and Finch, Malvern in Scarborough,��and Agincourt for high risk, and are looking for more participants. A further 350 were given a finger-prick blood test, which measures the amount of sugar coating on red blood cells as a measure of average blood sugar control over the last three months. Of these, 238 were found to be pre-diabetic – all of whom were previously undiagnosed.

Right now, there is no outreach screening or treatment program in the province for people with pre-diabetes. This study, funded by the Ontario Ministry of Health Promotion and the Ontario Trillium Foundation, is an important step toward changing that, say Riddell and Rowan.

Through community partnerships, all of those screened through the PRE-PAID Program with pre-diabetes are being given educational training on diabetes prevention and are provided with accessible and culturally preferred exercise sessions for six months.

Right: PRE-PAID participants in a bollyfit class

“The advantage of having the study at 91��ɫ is they can use the students from the School of Kinesiology to hold the classes and many of them are of the same ethnicity as the participants, so we’re breaking down some of the cultural and language barriers,” says Rowan. “Because we are so multicultural here, that really works.”

So instead of expecting study participants to join a gym and run on the treadmill for half an hour a day, the project offers things like bollyfit, socasize, reggaerobics, line dancing and tai chi in easily accessible community centres with certified exercise physiologists, for free. The participants are also asked to incorporate walking into their weekly routine.

Through the PRE-PAID Program, participants who have been identified as pre-diabetic are “provided with the opportunity and the encouragement. Then we track them to see how they comply,” says Rowan. “If it’s going to be sustainable, they really have to make that decision and that commitment.” The participants are assessed at the beginning, at three months and again at six months.

Some of the factors that stand in the way of participating in fitness programs are cost, time and priorities. “People are busy and have other pressing priorities, priorities we can’t even imagine,” says Riddell. “We’re trying to alleviate some of these barriers.”

By looking at studies done in the United States, India and China, “we know that by doing 150 minutes of moderate intensity exercise per week, about 30 minutes a day, five days a week, we can lower the risk of developing diabetes from a state of pre-diabetes by about 50 per cent,” says Riddell. “What is novel about this approach is we want to give them physical exercise that taps into culturally preferred activities. This is the first study I’m aware of that has done that.”

The incidence of pre-diabetes and Type 2 diabetes continues to rise in Canada. It is estimated that about seven per cent (two million) of Canadians have diabetes with about half of them undiagnosed, while another five to seven per cent have pre-diabetes.

“All the research has shown that exercise is the most effective preventative tool, even independent of dietary change,” says Riddell. So it makes sense that people at the highest risk of becoming pre-diabetic would be caught early on.

The researchers are currently seeking funding for Phase 3 of the project. In Phase 3, the team will recruit an additional 500 to 1,000 subjects and will extend the eligible age range to 18 to 64, as recent findings have shown there is an increasing incidence of diabetes in young people.

The group is presenting some of their preliminary results at the International Congress on Physical Activity & Public Health, May 5 to 8 in Toronto.

For more information, visit the Diabetes Prevention Program Web site or contact Chip Rowan at 647-378-6777 or stopdiab@yorku.ca. For more information about diabetes, visit the Web site.

By Sandra McLean, YFile writer

Republished courtesy of YFile– 91��ɫ’s daily e-bulletin.

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91��ɫ professor studying how mobile devices like a BlackBerry can help manage your weight

fmaquito — Tue, 20 Apr 2010 08:00:00 +0000

For 91��ɫ researcher and health psychologist Paul Ritvo, a professor in 91��ɫ’s School of Kinesiology & Health Science in the Faculty of Health, the has potential to help manage chronic diseases, such as Type 2 diabetes, wrote the Toronto Star April 18:

Ritvo has pioneered a study, currently underway, that hopes to explore how mobile technologies such as BlackBerrys can be used as a way of reinforcing good health habits by facilitating ongoing feedback.

Harvey Skinner, the dean of 91��ɫ’s Faculty of Health and a colleague of Ritvo’s, says “motivational drift” can make it difficult for people to continue with healthy behavioural changes. “We start off with good intentions, maybe initiate a change, say an exercise program, and then days later, weeks later, months later, we start encountering some challenges in keeping to our goal and in keeping to the routine.”

The key, Skinner suggests, is ongoing feedback, and mobile technologies are a tool with the capacity to provide that kind of around-the-clock communication between a patient and a health provider.

According to Ritvo, the goal of the “engaged health coaching program” is to make the patients, who are part of a community that reports high rates of diabetes, to “really feel there’s somebody who is very concerned about your health, and is giving you the best information you can get at the times when you most need it.”

In the long run, this kind of care has the potential to reduce the strain on the health-care system.

“I see this as the first step of trying to apply it to a whole range of health problems, including depression, for example, where there wouldn’t be a physical problem, but there would be ways where people could alter their lifestyles so as to support their moods,” says Ritvo.

The complete article is available on the .

Republished courtesy of YFile– 91��ɫ’s daily e-bulletin.

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