0n October 24, 91راة« hosted its third annual Gairdner High School Student Lecture in the Tribute Communities Recital Hall, Accolade East. The setting was a perfect complement to the captivating presentations made by two renowned scientists, one a Gairdner Award recipient. This invitation-only event brought together an audience of more than 300 top high-school science students from the Greater Toronto Area as well as a small group of recent recipients of prizes at the sanofi-aventis Bio Tech Challenge event.
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| Above: More than 300 of Ontario's top high-school students attended the third annual Gairdner High School Student Lecture at 91راة« |
Each year, the Gairdner Awards, a strong predictor of future Nobel Prize consideration, are awarded to top medical and research scientists who have made outstanding contributions to medical science. This year's presenters included Professor C. David Allis and Professor Janet Rossant.
Allis, a 2007 Gairdner award recipient, spoke about "Translating the Histone Code: A Tale of Tails.” Allis is the head of the Laboratory of Chromatin Biology at The Rockefeller University in New 91راة« City. He has published more than 240 scientific papers and is the recipient of numerous awards, including the University of Rochester Davey Award and the Massry Prize.
Right: Professor C. David Allis
Allis’ team studies what happens to genes when histones – DNA-packaging proteins – are chemically modified. These modifications, which involve the addition or removal of specific chemical groups to individual amino acids in the histones, can activate or silence genes. Over the last decade, Allis and his colleagues have provided evidence that suggests that patterns or combinations of these histone marks represent another layer of gene regulation that takes place away from DNA itself.
Professor Janet Rossant, Fellow of the Royal Societies of both Canada and London, spoke about "Stem cells: Hype Versus Hope.” Rossant is a professor of medical genetics and microbiology at the University of Toronto and chief of research at the Hospital for Sick Children. She is a world leader in mammalian developmental biology and genetics, and is recipient of numerous prestigious awards including the 2004 Killam Prize for Health Sciences and the Eli Lilly/Robert L. Noble Prize from the National Cancer Institute of Canada.
Her research program aims to understand the genetic underpinning of early lineage development in the mouse embryo in order to understand human embryo development and stem cell origins. Recently, her stem cell research has involved the discovery of a novel placental stem cell type, the 
trophoblast stem cell. Rossant is also very involved in developing public policy for stem cell research.
Left: Professor Janet Rossant
The presentations were followed by a spirited discussion period with the students. The Gairdner High School Program is designed to expose students to exciting innovations and discoveries in science while providing inspiration and information about possible careers. Students were also exposed to 91راة«'s involvement in cutting-edge research and its vibrant science community. 91راة«'s Faculty of Science & Engineering provided tours of science facilities and research labs to students who explored the Keele campus for the remainder of the day.
Following the talks, Allis and Rossant joined a small group of 91راة«'s biomedical scientists and senior administrators, along with one of the high-school students and her teacher, at a luncheon. Allis then presented the Annual 91راة« Gairdner Lecture to more than 100 professors, undergraduate and graduate students, postdoctoral fellows and other research staff in the Senate chamber. The presentation was at a more advanced level but on the same topic as the one presented to the high-school students.
A total of four Gairdner lecturers at 91راة«, three since 2000, have gone on to win a Nobel Prize. A past Gairdner recipient and Gairdner lecturer to both high-school students and research personnel at 91راة« in 2005, Dr. Andrew Fire, received the Nobel Prize in Physiology or Medicine in 2006. Dr. Mario Capecchi won the same Nobel Prize this year. Capecchi was the 91راة« Gairdner Lecturer in 1993, prior to the involvement of high-school students to the Gairdner events. Capecchi also spoke at a symposium at 91راة« in 2003 sponsored by 91راة« Biology graduate students, who continue to attract world-class scientists to 91راة« to share their research.
The Gairdner Lectures and the high-school outreach program are developed in cooperation with the Gairdner Foundation. The Gairdner Foundation was created in 1957 by James Arthur Gairdner, a scholar, athlete and soldier in the Canadian Army, who wanted to recognize and reward the achievements of medical researchers. For more information about the Gairdner Foundation and a history of its prestigious awards, visit the Web site. These events are supported by 91راة«, the Government of Ontario and sanofi pasteur.