Jacob O'Brien
Undergraduate biology student, Jacob O鈥橞rien, has won first prize for his oral presentation at the Southern Ontario Reproductive Biology (SORB) workshop held at McMaster University in Hamilton, ON.
O鈥橞rien works with Faculty of Science biology Professor Chun Peng, whose research focuses on women's reproductive health, particularly the role of microRNA in normal placental development, pregnancy complications and ovarian cancer.
Although postdoctoral fellows and PhD students who work with Peng have won numerous oral and poster presentation awards at SORB, this is a first for an undergraduate student in her lab. 鈥淛acob is a highly talented and motivated student and I am delighted that he won the award,鈥 says Peng. 鈥淭his is a reflection of the quality of undergraduate theses in the Department of Biology at 91亚色.鈥
MicroRNAs are small non-coding RNAs that the amount of specific proteins in a cell primarily by interacting with messenger RNAs and impacting protein synthesis. O鈥橞rien鈥檚 undergraduate thesis was to determine how a microRNA, miR-218, regulated placental cell gene expression.聽 Specifically, he developed a miRNA-DNA target prediction algorithm to determine which DNA sequences miR-218 interacts with. The algorithm can be applied to other microRNAs and therefore will be a useful tool in microRNA research.
鈥淢y work, I hope, will positively benefit the biology community by further increasing the knowledge of regulatory mechanisms that control protein levels within the immensely complex system we call the cell,鈥 says O鈥橞rien.
The annual event provides a venue for professors, graduate and undergraduate students to connect with other colleagues in their field and present their research in the area of reproductive biology.