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Publications

  1. Feng Y, Barbulescu P, Chana CK, Shirdarreh M, Yang H, Wu L, Mamand S, Kashem M, Zia A, Han M, Tsao J, Pugh T, Cescon D, Schatz DG, Sicheri F, Martin A, Pezo RC. FAM72A promotes UNG2 degradation and mutagenesis in human cancer cells. Sci Rep. 2025 Jul 2;15(1):23467. doi: 10.1038/s41598-025-07723-x. PMID: 40604025; PMCID: PMC12223117.
  2. Chelico L, Feng Y. In vitro deamination assay to measure the activity and processivity of AID/APOBEC enzymes. Methods Enzymol. 2025;713:69-100. doi: 10.1016/bs.mie.2024.11.038. Epub 2024 Dec 14. PMID: 40250961.
  3. Barbulescu P, Chana CK, Wong MK, Ben Makhlouf I, Bruce JP, Feng Y, Keszei AFA, Wong C, Mohamad-Ramshan R, McGary LC, Kashem MA, Ceccarelli DF, Orlicky S, Fang Y, Kuang H, Mazhab-Jafari M, Pezo RC, Bhagwat AS, Pugh TJ, Gingras AC, Sicheri F, Martin A. FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation. Nat Commun. 2024 Aug 30;15(1):7541. doi: 10.1038/s41467-024-52009-x. PMID: 39215025; PMCID: PMC11364545.
  4. Yuqing Feng, Bhupesh Thakur, Jeffery Bruce, Sami Mamand, Melika Shirdarreh, Matthew Wong, Jennifer Silvester, Ming Han, Mohammad Kashem, Amin Zia, David Cescon, Tervor Pugh, Rossanna C. Pezo, Alberto Martin. The FAM72 gene family promotes cancer development by disabling the base excision repair system [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1217.
  5. Feng Y, Martin A. Mutagenic repair during antibody diversification: emerging insights. Trends Immunol. 2022 Aug;43(8):604-607. doi: 10.1016/j.it.2022.05.004. Epub 2022 Jun 11. PMID: 35701290.
  6. Feng Y, Li C, Stewart JA, Barbulescu P, Seija Desivo N, 脕lvarez-Quil贸n A, Pezo RC, Perera MLW, Chan K, Tong AHY, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Kardar GA, Carlyle JR, Moffat J, Durocher D, Di Noia JM, Bhagwat AS, Martin A. FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature. 2021 Dec;600(7888):324-328. doi: 10.1038/s41586-021-04144-4. Epub 2021 Nov 24. PMID: 34819670; PMCID: PMC9425297.
  7. Kaake RM, Echeverria I, Kim SJ, Von Dollen J, Chesarino NM, Feng Y, Yu C, Ta H, Chelico L, Huang L, Gross J, Sali A, Krogan NJ. Characterization of an A3G-VifHIV-1-CRL5-CBF尾 Structure Using a Cross-linking Mass Spectrometry Pipeline for Integrative Modeling of Host-Pathogen Complexes. Mol Cell Proteomics. 2021;20:100132. doi: 10.1016/j.mcpro.2021.100132. Epub 2021 Aug 11. PMID: 34389466; PMCID: PMC8459920.
  8. Feng Y, Seija N, Di Noia JM, Martin A. AID in Antibody Diversification: There and Back Again. Trends Immunol. 2020 Jul;41(7):586-600. doi: 10.1016/j.it.2020.04.009. Epub 2020 Apr 27. Erratum in: Trends Immunol. 2021 Jan;42(1):89. doi: 10.1016/j.it.2020.10.011. PMID: 32434680; PMCID: PMC7183997.
  9. Morse M, Naufer MN, Feng Y, Chelico L, Rouzina I, Williams MC. HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA. Elife. 2019 Dec 18;8:e52649. doi: 10.7554/eLife.52649. PMID: 31850845; PMCID: PMC6946564.
  10. Feng Y, Wong L, Morse M, Rouzina I, Williams MC, Chelico L. RNA-Mediated Dimerization of the Human Deoxycytidine Deaminase APOBEC3H Influences Enzyme Activity and Interaction with Nucleic Acids. J Mol Biol. 2018 Dec 7;430(24):4891-4907. doi: 10.1016/j.jmb.2018.11.006. Epub 2018 Nov 9. PMID: 30414963; PMCID: PMC6289724.
  11. Adolph MB, Love RP, Feng Y, Chelico L. Corrigendum: Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B. Nucleic Acids Res. 2018 Dec 14;46(22):12190-12191. doi: 10.1093/nar/gky1115. Erratum for: Nucleic Acids Res. 2017 Nov 16;45(20):11925-11940. doi: 10.1093/nar/gkx832. PMID: 30395282; PMCID: PMC6294488.
  12. Adolph MB, Love RP, Feng Y, Chelico L. Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B. Nucleic Acids Res. 2017 Nov 16;45(20):11925-11940. doi: 10.1093/nar/gkx832. Erratum in: Nucleic Acids Res. 2018 Dec 14;46(22):12190-12191. doi: 10.1093/nar/gky1115. PMID: 28981865; PMCID: PMC5714209.
  13. Morse M, Huo R, Feng Y, Rouzina I, Chelico L, Williams MC. Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G. Nat Commun. 2017 Sep 19;8(1):597. doi: 10.1038/s41467-017-00501-y. PMID: 28928403; PMCID: PMC5605669.
  14. Feng Y, Goubran MH, Follack TB, Chelico L. Deamination-independent restriction of LINE-1 retrotransposition by APOBEC3H. Sci Rep. 2017 Sep 7;7(1):10881. doi: 10.1038/s41598-017-11344-4. PMID: 28883657; PMCID: PMC5589869.
  15. Adolph MB, Ara A, Feng Y, Wittkopp CJ, Emerman M, Fraser JS, Chelico L. Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization. Nucleic Acids Res. 2017 Apr 7;45(6):3378-3394. doi: 10.1093/nar/gkx066. PMID: 28158858; PMCID: PMC5389708.
  16. Starrett GJ, Luengas EM, McCann JL, Ebrahimi D, Temiz NA, Love RP, Feng Y, Adolph MB, Chelico L, Law EK, Carpenter MA, Harris RS. The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis. Nat Commun. 2016 Sep 21;7:12918. doi: 10.1038/ncomms12918. PMID: 27650891; PMCID: PMC5036005.
  17. Feng Y, Love RP, Ara A, Baig TT, Adolph MB, Chelico L. Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability. J Biol Chem. 2015 Nov 6;290(45):27188-27203. doi: 10.1074/jbc.M115.666065. Epub 2015 Sep 22. PMID: 26396192; PMCID: PMC4646388.
  18. Baig TT, Feng Y, Chelico L. Determinants of efficient degradation of APOBEC3 restriction factors by HIV-1 Vif. J Virol. 2014 Dec;88(24):14380-95. doi: 10.1128/JVI.02484-14. Epub 2014 Oct 1. Erratum in: J Virol. 2017 Mar 13;91(7):e00079-17. doi: 10.1128/JVI.00079-17. PMID: 25275135; PMCID: PMC4249154.
  19. Feng Y, Baig TT, Love RP, Chelico L. Suppression of APOBEC3-mediated restriction of HIV-1 by Vif. Front Microbiol. 2014 Aug 26;5:450. doi: 10.3389/fmicb.2014.00450. PMID: 25206352; PMCID: PMC4144255.
  20. Feng Y, Love RP, Chelico L. HIV-1 viral infectivity factor (Vif) alters processive single-stranded DNA scanning of the retroviral restriction factor APOBEC3G. J Biol Chem. 2013 Mar 1;288(9):6083-94. doi: 10.1074/jbc.M112.421875. Epub 2013 Jan 11. PMID: 23316055; PMCID: PMC3585047.
  21. Feng Y, Chelico L. Intensity of deoxycytidine deamination of HIV-1 proviral DNA by the retroviral restriction factor APOBEC3G is mediated by the noncatalytic domain. J Biol Chem. 2011 Apr 1;286(13):11415-26. doi: 10.1074/jbc.M110.199604. Epub 2011 Feb 7. PMID: 21300806; PMCID: PMC3064197.